Overview of GLP-1 Receptor Agonists

A high-quality diet with a focus on protein intake and regular resistance training should be emphasized to minimize muscle loss.

GLP-1 receptor agonists are medications that mimic the effects of the hormone glucagon-like peptide 1, which is naturally produced by the body. They are known for helping with weight loss and managing type 2 diabetes.

Semaglutide is known by brand names such as Ozempic and Wegovy.

Ozempic is a lower dose version of semaglutide that has been FDA-approved for managing type 2 diabetes.

Wegovy is a higher dose version of semaglutide that has been FDA-approved for weight loss.

They slow gastric emptying, reduce appetite by acting on the brain, and help feel full longer.

They stimulate the release of insulin from the pancreas while inhibiting glucagon, thereby lowering blood glucose levels.

Their design increases their half-life, allowing them to last longer in the bloodstream and have a prolonged effect.

Common gastrointestinal side effects include nausea, vomiting, diarrhea, constipation, bloating, and abdominal pain.

Potential side effects may include pancreatitis, gallbladder issues, and in rare cases, concerns about thyroid cancer, mainly observed in rodent studies.

A significant concern is the loss of muscle mass along with fat, which can lead to a loss of absolute strength.

They are expensive because of high demand and the cost of brand-name drugs, sometimes over $1,000 a month without insurance.

Yes, decent insurance may cover much of the cost, though this depends on the specific insurance plan.

Individuals struggling with lifestyle changes like diet and exercise, who face long-term health risks from remaining overweight, may consider these medications.

Upon discontinuation, most individuals tend to gain back the weight they lost while on the medication.

Consider if it's worth the financial cost, side effects, and indefinite use, especially for losing only a small amount of weight.

GLP-1 receptor agonists should be paired with diet and exercise when used for weight loss.

Some individuals can effectively lose weight through consistent diet and exercise modifications alone.

They are encouraged to explore further tweaks to diet and exercise rather than resorting to medication.

They may reduce the risk of cardiovascular-related events in individuals with pre-existing conditions, possibly due to weight loss or reduced inflammation.

A high-quality diet with a focus on protein intake and regular resistance training should be emphasized to minimize muscle loss.

GLP-1 receptor agonists are medications that mimic the effects of the hormone glucagon-like peptide 1, which is naturally produced by the body. They are known for helping with weight loss and managing type 2 diabetes.