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An Introduction to Breast Cancer

Question 21

Which grading system is used for histologic grading of invasive breast carcinomas?

A.Nottingham-Cambridge

B.Bloom-Richardson

C.Gleason

D.AJCC

Question 1

What is a woman's lifetime risk of developing invasive breast cancer?

A.0.5%

B.3.8%

C.6.7%

D.12.5%

Question 2

What is the most significant risk factor for developing breast cancer, aside from gender?

A.Prior history of breast cancer

B.Alcohol consumption

C.Obesity

D.Increasing age

Question 3

According to the American Cancer Society, at what age should women of average risk begin annual mammogram screening?

A.30 years old

B.35 years old

C.40 years old

D.45 years old

Question 4

On average, screening mammograms detect what percentage of malignancies?

A.<1%

B.4%

C.10%

D.20%

Question 5

Magnetic Resonance Imaging (MRI) detects what percentage of otherwise occult contralateral malignancies in women recently diagnosed with breast carcinoma?

A.<1%

B.3-4%

C.10-15%

D.20-25%

Question 6

What is the most common cancer in women?

A.Lung cancer

B.Breast cancer

C.Colon cancer

D.Ovarian cancer

Question 7

Which breast quadrant is both most common for breast tissue and for cancer occurrence?

A.Upper Inner

B.Upper Outer

C.Lower Outer

D.Lower Inner

Question 8

What are the main components of breast parenchyma?

A.Fat and skin

B.Ribs and nerves

C.Lobules and ducts

D.Blood vessels and lymphatics

Question 9

Which lymph nodes are the most common site of breast cancer lymphatic involvement?

A.Inguinal nodes

B.Supraclavicular nodes

C.Internal mammary nodes

D.Axillary nodes

Question 10

Which gene mutations are most strongly associated with familial breast cancer?

A.p53 and PTEN

B.MYC and KRAS

C.BRCA1 and BRCA2

D.EGFR and BRAF

Question 11

For women with moderate risk of breast cancer, what additional screening tool may be considered annually starting at age 40?

A.Ultrasound

B.Clinical breast exam

C.MRI

D.Genetic testing

Question 12

Which type of invasive carcinoma is most common in breast cancer?

A.Invasive lobular carcinoma

B.Medullary carcinoma

C.Invasive ductal carcinoma

D.Mucinous carcinoma

Question 13

Which area does Paget's disease of the breast most commonly affect?

A.Lymph nodes

B.Nipple and areola skin

C.Upper outer quadrant

D.Axillary tail

Question 14

What is a characteristic benefit of women with hormone receptor-positive breast cancer?

A.Worse prognosis

B.Better response to hormone therapy

C.No treatment options

D.Higher recurrence rates

Question 15

HER2-positive breast cancers are more likely to benefit from which drug?

A.Tamoxifen

B.Arimidex

C.Herceptin

D.Femara

Question 16

According to the AJCC, what tumor size is classified as T1 in breast cancer staging?

A.≤2cm

B.≤5cm

C.>5cm

D.Any size with skin involvement

Question 17

What is the most common site for distant metastasis of breast cancer?

A.Brain

B.Bone

C.Lung

D.Liver

Question 18

Which U.S. population has a lower incidence of breast cancer but is usually diagnosed at a younger age and more advanced stage?

A.White women

B.Asian/Pacific Islanders

C.African American women

D.Hispanic women

Question 19

Which imaging tool is more sensitive for breast cancer detection in women at high familial risk?

A.Mammogram

B.MRI

C.Ultrasound

D.CT scan

Question 20

Which limitation is associated with breast MRI?

A.Not sensitive for dense breasts

B.Cannot detect bone metastases

C.High cost and false positive rate

D.Low sensitivity for lymph nodes